Pidisai Inj. 1g/ Pidisai Inj. 2g

Pharmaceutical ingredients: Piperacillin 1.0 g/ 2.0 g (as sodium piperacillin)

Assign

Severe infections, septicemia, and complicated urinary tract infections caused by susceptible bacteria, especially Pseudomonas. In cases of systemic infections caused by Pseudomonas or in patients with neutropenia, piperacillin must be combined with an aminoglycoside for treatment.

Postoperative infection of the abdomen and uterus.

How to use, dosage

Administration: Piperacillin is administered as sodium salt. Dosage is calculated based on the equivalent amount of piperacillin base and must be reduced in the presence of renal failure. The drug can be administered by slow intravenous injection over 3-5 minutes, intravenous infusion over 20-40 minutes, or deep intramuscular injection. Do not administer more than 2 g intramuscularly at a time (for adults) or more than 0.5 g (for children).

Intravenous infusion: Each gram of powder is mixed with at least 5 ml of distilled water, then diluted with infusion solution to 50 ml for infusion within 20 - 40 minutes.

Deep intramuscular injection: Each gram of powder is mixed with at least 2 ml of distilled water or 0.5 - 1% lignocaine solution. Suitable diluents for reconstitution: 5% glucose solution, 0.9% sodium chloride, lactated Ringer's solution, 5% glucose solution and 0.9% sodium chloride, 6% dextran in 0.9% sodium chloride solution, 30% glucose, 20% mannitol and distilled water for injection.

The medicine must be mixed immediately before use and any remaining solution must be discarded. However, the diluted medicine solution remains chemically stable for at least 24 hours at room temperature or 48 hours at 4°C.

Dosage

Adults (normal kidney function)

Intravenous injection 200 - 300 mg/kg body weight/24 hours, divided into 6 times. In severe, life-threatening infections suspected to be caused by Pseudomonas or Klebsiella, the daily dose should not be less than 16 g and the interval between treatment doses should be 4 - 6 hours, and administered intravenously.

The maximum daily dose is usually 24g (intravenous injection), however, higher doses can be used. For Pseudomonas aeruginosa bacteremia: Intravenous injection of gentamicin 4 - 5 mg/kg body weight/24 hours, or divided into 2 doses (12 hours apart) or a single dose, combined with piperacillin 3g, intravenous injection 4 hours apart (If the patient is allergic to piperacillin, inject ceftazidime 2g intravenously, every 8 hours). Treatment duration is 2 - 6 weeks, depending on the site of infection.

For patients with fever and neutropenia, empirical treatment with broad-spectrum antibiotics against Gram-negative bacilli and Pseudomonas aeruginosanot (blue pus bacilli): Intravenous injection of piperacillin 4g, every 6 hours, combined with gentamicin 4-5 mg/kg body weight/24 hours, injected once or divided into 2 injections 12 hours apart. Prevention of infection during surgery: Use a dose of 2g immediately before surgery, followed by at least two more doses, each dose of 2g, 6 or 8 hours apart; within 24 hours of surgery.

Children (normal renal function)

Children from 1 month to 12 years old: The usual dose is: 200 - 300 mg/kg body weight/24 hours. Divide the dose every 4 - 6 hours.

For infants (0 to 1 month old), the dose should be adjusted as follows:

Body weight under 2000g, use 50 mg/kg body weight/8 hours. Body weight over 2000g, use 50 mg/kg body weight/8 hours if the child is less than 7 days old; 75 mg/kg body weight/8 hours if the child is over 7 days old.

Adults with impaired renal function (70 kg weight), adjust the dose accordingly as follows:

Creatinine clearance is 41 - 80 ml/min, dose 4 g/8 hours.

Creatinine clearance is 21 - 40 ml/min, dose 4 g/12 hours.

Creatinine clearance less than 20 ml/min, use dose 4 g/24 hours.

Patients on hemodialysis: Maximum 2 g, every 8 hours; immediately after dialysis, use 1 g.

Children with impaired renal function: Dose and injection interval depend on plasma drug concentration. Children with severe urinary tract infections: 100 - 150 mg/kg/24 hours, intravenous injection.

Contraindications

Hypersensitivity to penicillin and/or cephalosporins.